TY - JOUR T1 - THE RENAL EXCRETION OF 4'-CARBOXYPHENYLMETHANE SULFONANILIDE (CARONAMIDE) JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 250 LP - 254 VL - 91 IS - 3 AU - DAVID P. EARLE, JR. AU - BERNARD B. BRODIE Y1 - 1947/11/01 UR - http://jpet.aspetjournals.org/content/91/3/250.abstract N2 - 1. Forty per cent of caronamide in dog plasma is bound on plasma protein at a drug concentration of 10 mgm. per cent and an albumin content of 3.5 grams per cent. 2. The overall renal clearance of caronamide in the dog is approximately one-half the filtration rate. 3. The average ratio of the clearance of caronamide, corrected for plasma binding, to glomerular filtration rate in 3 dogs is 1.30. The excretion of caronamide, therefore, is the result both of glomerular filtration and of some renal tubular excretion. 4. Evidence is presented for the occurrence of a metabolic product of caronamide in the plasma of 3 dogs, and in the urine of 2 of the 3 dogs. 5. Fifty-nine per cent of administered caronamide was recovered in the urine in a single experiment as caronamide. There was also evidence of an appreciable amount of caronamide metabolic product in the urine. 1946 by The American Society for Pharmacology and Experimental Therapeutics ER -