TY - JOUR T1 - THE ESTIMATION OF 4'-CARBOXYPHENYLMETHANE SULFONANILIDE (CARONAMIDE) IN BIOLOGICAL FLUIDS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 246 LP - 249 VL - 91 IS - 3 AU - BERNARD B. BRODIE AU - BETTY LEVY AU - ELEANORE BERNSTEIN Y1 - 1947/11/01 UR - http://jpet.aspetjournals.org/content/91/3/246.abstract N2 - Simple spectrophotometric methods are described for the estimation of caronamide (4'-carboxyphenylmethane sulfonanilide) in biological fluids. Caronamide is isolated from biological material by an extraction with chloroform at an acid pH. The compound is then returned to alkali and the concentration measured spectrophotometrically at 280 mµ. This method is specific in the case of the dog in that metabolic derivatives of caronamide do not interfere. Another procedure measures the caronamide spectrophotometrically in protein fitrates of plasma. This method is simpler but less specific than the extraction procedure in that metabolic derivatives of caronamide interfere in the measurement. 1946 by The American Society for Pharmacology and Experimental Therapeutics ER -