@article {ROGOFF57, author = {J. M. ROGOFF and DAVID MARINE}, title = {EFFECT ON TADPOLES OF FEEDING THYROID PRODUCTS OBTAINED BY ALKALINE HYDROLYSIS}, volume = {9}, number = {1}, pages = {57--73}, year = {1916}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Hydrolysis of whole thyroid after the method of Kendall, concentrates the substance producing the characteristic metabolic effect of thyroid. Kendall designates this substance product "A." The iodin contents of the products we obtained were about 6-7 times as high as those of the whole glands and the pharmacological activity approximately 12 times as great. The activity of product "A" is proportional to the iodin content. Product "A" does not produce symptoms of poisoning in guinea pigs, when introduced intraperitoneally. It has long been known that the activity of whole thyroid is in general proportional to its iodin content and also that iodin-free thyroid is inactive and we have shown that an iodin-free product "A" is also inactive. Attempts to activate it by artificial iodization were negative. Product "B" and the "Residue," although they contain iodin are apparently inactive. The slight loss of weight of the tadpoles noted in most of the experiments might be due to incomplete hydrolysis or incomplete separation of product "A," in as much as the method is a crude one. This method of hydrolysis has afforded an additional means of establishing the fact that the thyroid normally contains both active and inactive iodin in varying amounts. Our experiments confirm the statements of Morse and of Lenhart that "Iodalbin" has a thyroid-like action on tadpoles, but this action takes place more slowly.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/9/1/57}, eprint = {https://jpet.aspetjournals.org/content/9/1/57.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }