PT  - JOURNAL ARTICLE
AU  - HENRY W. ELLIOTT
AU  - ALBERT E. WARRENS
AU  - HAL P. JAMES
TI  - SOME EFFECTS OF 1-METHYL-4-PHENYL ETHYL ISONIPECOTATE (DEMEROL) AND 6-DIMETHYLAMINO-4,4,-DIPHENYL-3-HEPTANONE (AMIDONE) UPON THE METABOLISM OF RAT BRAIN TISSUE IN VITRO
DP  - 1947 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 98--102
VI  - 91
IP  - 2
4099  - http://jpet.aspetjournals.org/content/91/2/98.short
4100  - http://jpet.aspetjournals.org/content/91/2/98.full
SO  - J Pharmacol Exp Ther1947 Oct 01; 91
AB  - The effects of demerol and amidone in vitro on the respiration and anaerobic glycolysis of brain tissue preparations have been studied by conventional manometric methods. Amidone is ten times as potent an inhibitor of glucose oxidation as demerol and stimulates oxygen uptake at low concentrations. The inhibitory action of these drugs is presumably due to an action on the dehydrogenases involved in glucose oxidation.