RT Journal Article
SR Electronic
T1 THE TOXICITY AND GENERAL PHARMACOLOGY OF N<sub>1</sub>-<em>p</em>-CHLORO-PHENYL-N<sub>5</sub>-ISOPROPYL BIGUANIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 157
OP 160
VO 91
IS 2
A1 K. K. CHEN
A1 ROBERT C. ANDERSON
YR 1947
UL http://jpet.aspetjournals.org/content/91/2/157.abstract
AB 1. The acute toxicity of N1-p-chlorophenyl-N5-isopropyl biguanide HCl has been compared with quinine 2HCl and quinacrine HCl in mice, rats, guinea pigs, and rabbits. 2. The biguanide has been repeatedly administered in various doses to rats. No pathologic lesions can be demonstrated, and death from large doses may be attributed to acute systemic effects. 3. The biguanide lowers blood pressure with an acceleration of respiratory rate in anesthetized cats. 4. With the exception of the isolated guinea pig's uterus, which responds by contraction, the biguanide has an inherently relaxing property on the isolated rabbit's uterus and intestine, and the isolated guinea pig's intestine. 5. The action of the biguanide on the blood sugar of rabbits is suggestive of a slight hypoglycemia.