TY - JOUR T1 - THE ROLE OF THE LIVER IN THE DETOXICATION OF THIOPENTAL (PENTOTHAL) AND TWO OTHER THIOBARBITURATES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 331 LP - 339 VL - 91 IS - 4 AU - F. E. SHIDEMAN AU - A R. KELLY AU - B. J. ADAMS Y1 - 1947/12/01 UR - http://jpet.aspetjournals.org/content/91/4/331.abstract N2 - 1. Carbon tetrachloride liver damage in mice significantly prolonged the duration of effect of Pentothal Sodium and two other thiobarbiturates. 2. Subtotal hepatectomy in rats produced a significant prolongation of the duration of action of Pentothal. 3. Diminished blood flow through the liver, as produced by the Eck fistula technic in rats, increased the duration of action of Pentothal and the two other thiobarbiturates tested. 4. Pentothal was degraded in vitro by rat liver slices and mince. ER -