RT Journal Article
SR Electronic
T1 THE ACUTE JOINT TOXICITY OF ATABRINE, QUININE, HYDROXYETHYLAPOCUPREINE, PAMAQUINE AND PENTAQUINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 133
OP 139
VO 91
IS 2
A1 GRAHAM CHEN
A1 E. M. K. GEILING
YR 1947
UL http://jpet.aspetjournals.org/content/91/2/133.abstract
AB The acute lethal toxicities of atabrine and quinine, quinine and hydroxyethylapocupreine, atabrine and pamaquine, quinine and pamaquine, quinine and pentaquine, were investigated by intraperitoneal injection in mice. It was found that the combinations of these antimalarials are different in their joint toxicity: (1) Atabrine and quinine, quinine and hydroxyethylapocupreine, act independently and similarly (2) Atabrine in sublethal doses and pamaquine act independently but diversely. (3) Quinine and pamaquine, quinine and pentaquine are synergistic in their joint action.