PT  - JOURNAL ARTICLE
AU  - GRAHAM CHEN
AU  - E. M. K. GEILING
TI  - THE ACUTE JOINT TOXICITY OF ATABRINE, QUININE, HYDROXYETHYLAPOCUPREINE, PAMAQUINE AND PENTAQUINE
DP  - 1947 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 133--139
VI  - 91
IP  - 2
4099  - http://jpet.aspetjournals.org/content/91/2/133.short
4100  - http://jpet.aspetjournals.org/content/91/2/133.full
SO  - J Pharmacol Exp Ther1947 Oct 01; 91
AB  - The acute lethal toxicities of atabrine and quinine, quinine and hydroxyethylapocupreine, atabrine and pamaquine, quinine and pamaquine, quinine and pentaquine, were investigated by intraperitoneal injection in mice. It was found that the combinations of these antimalarials are different in their joint toxicity: (1) Atabrine and quinine, quinine and hydroxyethylapocupreine, act independently and similarly (2) Atabrine in sublethal doses and pamaquine act independently but diversely. (3) Quinine and pamaquine, quinine and pentaquine are synergistic in their joint action.