TY - JOUR T1 - THE EFFECT OF DI-ISOPROPYL FLUOROPHOSPHATE ON NEUROMUSCULAR TRANSMISSION JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 77 LP - 83 VL - 91 IS - 1 AU - CARLTON C. HUNT Y1 - 1947/09/01 UR - http://jpet.aspetjournals.org/content/91/1/77.abstract N2 - The effect of the intra-arterial injection of DFP and other cholinergic agents on the response of the cat gastrocnemius to maximal single nerve shocks is described. 1. DFP causes a potentiation like that seen following physostigmine. 2. DFP sensitizes the muscle to the close intra-arterial injection of acetylcholine. 3. DFP is less effective in antagonizing the depression of neuromuscular function caused by curare than is prostigmine. 4. Additional evidence is advanced for a direct action of prostigmine on skeletal muscle. ' A comparative study has been made of the actions of DFP, prostigmine, and physostigmine. 5. In relation to these data, the role of cholinesterase in neuromuscular transmission is discussed. ER -