PT  - JOURNAL ARTICLE
AU  - PAUL K. SMITH
AU  - HELEN L. GLEASON
AU  - C. G. STOLL
AU  - S. OGORZALEK
TI  - STUDIES ON THE PHARMACOLOGY OF SALICYLATES
DP  - 1946 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 237--255
VI  - 87
IP  - 3
4099  - http://jpet.aspetjournals.org/content/87/3/237.short
4100  - http://jpet.aspetjournals.org/content/87/3/237.full
SO  - J Pharmacol Exp Ther1946 Jul 01; 87
AB  - 1. Colorimetric methods have been developed for the determination in urine of free salicylate, salicyluric acid and total salicylates. 2. Most of the salicylate in human plasma is bound to the non-diffusible components, presumably plasma proteins. 3. Even at high plasma salicylate concentrations very little salicylate is in human erythrocytes. 4. After the oral administration of aspirin to human subjects or oral or intravenous administration to dogs the only detectable form of salicylate in the plasma is free salicylate. 5. The administration of sodium bicarbonate along with salicylates results in lower plasma levels than when the salicylate alone is given. 6. The administration of sodium bicarbonate to patients receiving sodium salicylate results in an increased excretion of free salicylate, with the renal clearances of free salicylate increasing rapidly above pH 7 in the urine. 1946 by The American Society for Pharmacology and Experimental Therapeutics