RT Journal Article
SR Electronic
T1 THE ACTION OF TETRAETHYLAMMONIUM ION ON THE MAMMALIAN CIRCULATION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 220
OP 236
VO 87
IS 3
A1 GEORGE H. ACHESON
A1 GORDON K. MOE
YR 1946
UL http://jpet.aspetjournals.org/content/87/3/220.abstract
AB The actions of tetraethylammonium bromide upon the circulatory system of the cat and dog have been described and analyzed. Over a wide range of doses (0.1 to 10 mgm. per kgm.). intravenous injections of this material produce falls of arterial pressure whose magnitude is a function of the dose and which last several minutes. The heart rate is usually diminished moderately, and this effect is absent if the cardiac innervation is severed. The fall of arterial pressure is shown not to depend upon actions on tile heart, the vascular smooth muscle, or the medullary vasomotor center. It results from a block in the ganglia in the efferent pathway of the sympathetic vasoconstrictor nerves. This ganglionic blocking action has been demonstrated in the superior cervical ganglion, the stellate ganglion, and the ganglia of the cardio-inhibitory fibers of the vagus. The ganglionic blocking action of tetraethylammonium ion is shown to be its most prominent effect. Side effects are absent with all but the largest doses of this substance. 1946 by The American Society for Pharmacology and Experimental Therapeutics