PT  - JOURNAL ARTICLE
AU  - ELIZABETH TAYLOR
AU  - FRED H. SNYDER
AU  - FRED W. OBERST
TI  - URINARY AND FECAL EXCRETION OF SULFANILAMIDE DERIVATIVES AFTER ORAL ADMINISTRATION TO RATS
DP  - 1947 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 154--160
VI  - 90
IP  - 2
4099  - http://jpet.aspetjournals.org/content/90/2/154.short
4100  - http://jpet.aspetjournals.org/content/90/2/154.full
SO  - J Pharmacol Exp Ther1947 Jun 01; 90
AB  - An investigation has been made of twenty previously unreported sulfanilamide derivatives. Following oral administration to rats, ten of the compounds are excreted largely in the feces, one chiefly in the urine, and one is almost equally divided between the two materials. Two 4-isothiocyanobenzenesulfonamides gave interesting and unexpected results. There appears to be a substance in normal rat feces, and in acetone extracts thereof, which in some way prevents full color development by these compounds after hydrolysis. The remaining seven compounds are hydrolyzed with difficulty, and a satisfactory analytical method has not yet been worked out. 1946 by The American Society for Pharmacology and Experimental Therapeutics