PT - JOURNAL ARTICLE AU - A. M. LANDS AU - V. L. NASH AU - H. M. McCARTHY AU - H. R. GRANGER AU - B. L. DERTINGER TI - THE PHARMACOLOGY OF N-ALKYL HOMOLOGUES OF EPINEPHRINE DP - 1947 Jun 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 110--119 VI - 90 IP - 2 4099 - http://jpet.aspetjournals.org/content/90/2/110.short 4100 - http://jpet.aspetjournals.org/content/90/2/110.full SO - J Pharmacol Exp Ther1947 Jun 01; 90 AB - 1. The replacement of the N-methyl group of epinephrine by -isopropyl or-sec. butyl groups results in compounds that are strongly depressor. Thisdepressor action is comparable to that sometimes elicitable with epinephrine. 2. The homologues of epinephrine have a direct stimulating effect on the heart. 3. The N-isopropyl and -sec. butyl homologues of epinephrine dilate thebronchioles, relax the small intestine, colon, and uterus, when present in highdilution. 4. The N-isopropyl homologue appears to be somewhat more effective thanthe N-sec. butyl homologue. 5. The possible role of these agents as sympathin I-mimetic agents is discussed. 1946 by The American Society for Pharmacology and Experimental Therapeutics