PT  - JOURNAL ARTICLE
AU  - HENRY M. LEE
AU  - WILLIAM G. DINWIDDIE
AU  - K. K. CHEN
TI  - THE ANTIHISTAMINE ACTION OF N-(2-PYRIDYL)-N-(2-THENYL)-N',N'-DIMETHYLETHYLENEDIAMINE HYDROCHLORIDE
DP  - 1947 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 83--87
VI  - 90
IP  - 1
4099  - http://jpet.aspetjournals.org/content/90/1/83.short
4100  - http://jpet.aspetjournals.org/content/90/1/83.full
SO  - J Pharmacol Exp Ther1947 May 01; 90
AB  - 1. N-(2-Pyridyl)-N-(2-thenyl)-N',N'-dimethylethylenediamine HCl, designated as 01013, has a potent antihistamine action as proved by its inhibition of histamine effect on the isolated guinea pig's small intestines, the intact guinea pig placed in a histamine atmosphere, and the blood pressure of anesthetized cats. 2. The compound augments the pressor action of epinephrine. 3. Its toxicity in mice has been determined. 4. There is evidence that 01013 given by mouth may be efficacious in the treatment of hay fever.