PT  - JOURNAL ARTICLE
AU  - RICHARD J. HENRY
AU  - SAM BERKMAN
AU  - RILEY D. HOUSEWRIGHT
TI  - STUDIES ON STREPTOMYCIN
DP  - 1947 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 42--45
VI  - 90
IP  - 1
4099  - http://jpet.aspetjournals.org/content/90/1/42.short
4100  - http://jpet.aspetjournals.org/content/90/1/42.full
SO  - J Pharmacol Exp Ther1947 May 01; 90
AB  - The activity of streptomycin was found to decrease while in solution in several bacteriological culture media, human serum, and human plasma. Maximum losses ranged up to 75%. Practically all the loss in activity occurred within the first twenty-four hours. The composition of the environment and the physical factors of time, temperature, and concentrations of streptomycin were found to be significant variables in this loss of potency. It is postulated that the observed loss in potency is the result of adsorption onto constituents of these environments.