TY - JOUR T1 - STUDIES ON STREPTOMYCIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 42 LP - 45 VL - 90 IS - 1 AU - RICHARD J. HENRY AU - SAM BERKMAN AU - RILEY D. HOUSEWRIGHT Y1 - 1947/05/01 UR - http://jpet.aspetjournals.org/content/90/1/42.abstract N2 - The activity of streptomycin was found to decrease while in solution in several bacteriological culture media, human serum, and human plasma. Maximum losses ranged up to 75%. Practically all the loss in activity occurred within the first twenty-four hours. The composition of the environment and the physical factors of time, temperature, and concentrations of streptomycin were found to be significant variables in this loss of potency. It is postulated that the observed loss in potency is the result of adsorption onto constituents of these environments. ER -