RT Journal Article SR Electronic T1 THE RATE OF DISAPPEARANCE OF A MARIHUANA-ACTIVE SUBSTANCE FROM THE CIRCULATING BLOOD JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 294 OP 296 VO 86 IS 3 A1 S. LOEWE YR 1946 UL http://jpet.aspetjournals.org/content/86/3/294.abstract AB The persistence in the blood stream of parahexyl, a synthetic marihuana active substance, was studied in dogs. Large doses were injected by vein, and the blood concentration was determined at varying intervals by assay of the ataxia action of blood extracts in test dogs. One to ten per cent of the injected dose was found circufating between two and eleven hours after the injection. In one animal about one per cent of an intravenous dose was recovered in the lungs after twenty hours. 1946 by The American Society for Pharmacology and Experimental Therapeutics