TY - JOUR T1 - THE PHARMACOLOGY OF THE VAS DEFERENS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 551 LP - 559 VL - 8 IS - 9 AU - J. A. WADDELL Y1 - 1916/09/01 UR - http://jpet.aspetjournals.org/content/8/9/551.abstract N2 - 1. The freshly excised vasa deferentia of the rabbit and the rat exhibit rhythmic contractions when suspended in oxygenated Tyrode's or Ringer's solution at body temperature. 2. The vasa deferentia of dogs, rabbits, rats, guinea pigs, and sheep exhibit increased tone and rhythmic contractions upon application of epinephrine, ergot, hydrastinine, pilocarpine, nicotine, and barium chloride. All parts of the organ react essentially alike. 3. Pituitary extract produced no effect on the quiescent vasa deferentia of any of the animals examined. 4. The vas deferens is a very responsive and very resistent organ and it may prove of value in the physiological standardization of certain drugs. I already have under way further investigations of the reactions of the vas deferens, and of other portions of the male generative tract. These will be reported at an early date. ER -