RT Journal Article
SR Electronic
T1 ON THE ELIMINATION OF G-STROPHANTHIN BY THE RAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 248
OP 257
VO 86
IS 3
A1 ALFRED FARAH
YR 1946
UL http://jpet.aspetjournals.org/content/86/3/248.abstract
AB In rats Under anaesthesia, the lethal dose of g-strophanthin is reduced by partial or total (functional) hepatectomy (evisceration). This reduction is pro-portional to the log of percentage hepatectomy. Liver hypertrophy following removal of the median and left lateral lobes of the liver is accompanied by a gradual increase in the lethal dose of g-strophanthin. This increase is not directly proportional to the increase in liver weight. In in vitro experiments with rat blood and rat liver slices no appreciable destruction of g-strophanthin can be demonstrated. Rat liver slices combine with g-strophanthin. This combination is inhibited by HCN and does not occur in the absence of oxygen. The elimination of g-strophanthin is markedly reduced by evisceration. Following the infusion of g-strophanthin appreciable quantities of cardioactive material can be detected in the bile of the rat. In the light of previous experimental findings and our own data, the mechanism of g-strophanthin elimination has been discussed, and it is concluded that in the rat the hepatic route of excretion is the main route of elimination of g-strophanthin. 1946 by The American Society for Pharmacology and Experimental Therapeutics