TY - JOUR T1 - THE PHARMACOLOGIC ACTIVITY OF N-METHYL-β-CYCLOHEXYLISOPROPYLAMINE HYDROCHLORIDE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 382 LP - 385 VL - 89 IS - 3 AU - A. M. LANDS AU - V. L. NASH AU - H. R. GRANGER AU - B. L. DERTINGER Y1 - 1947/03/01 UR - http://jpet.aspetjournals.org/content/89/3/382.abstract N2 - 1. Racemic N-methyl-β-cyclohexylisopropylamine HCl has about two-thirds of the pressor activity of its phenyl analogue (racemic desoxyephedrine HCl). 2. 1-N-Methyl-β-cyclohexylisopropylamine HCl is more pressor and more excitatory on the central nervous system than is the d-isomer. 3. d-N-Methyl-β-phenylisopropylamine HCl is more pressor and more excitatory on the central nervous system than is the l-isomer. 4. All the isomers of N-methy1-β-cyclohexylisopropylamine HCl and N-methyl -β-phenylisopropylamine HCl were found to have the same acute toxicity in mice. 5. Racemic Neo-Synephrine HCl is approximately twenty-five times more pressor than racemic N-methyl-β-cyclohexylisopropylamine HCl, approximately seventeen times more pressor than N-methyl-β-phenylisopropylamine HCl and is approximately one-sixth as toxic. 1947 by The American Society for Pharmacology and Experimental Therapeutics ER -