RT Journal Article
SR Electronic
T1 ELECTROCARDIOGRAPHIC CORRELATIONS WITH DIGITALIS BIOASSAY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 177
OP 185
VO 86
IS 2
A1 JOHN C. SCOTT
A1 NORMAN C. WHEELER
YR 1946
UL http://jpet.aspetjournals.org/content/86/2/177.abstract
AB A statistical study of electrocardiographic changes during the bioassay of digitalis by the USP XII method indicates the following: (1) Under ether anesthesia coupling is more frequent before than after the infusion of digitalis. (2) The P-R interval for a given heart rate is smaller under the influence of digitalis. (3) The average dose at which the maximum R-R Q-T ratio, minimum rate, S-T segment deviation, ectopic beats, ventricular fibrillation and cardiac death occur, varies with the dose producing A-V dissociation. (4) When the cases are grouped according to the dose producing A-V dissociation, the interval between this event and the lethal dose tends to be a constant one. (5) Mean blood pressure bears no significant relationship to the electrocardiographic findings. 1946 by The American Society for Pharmacology and Experimental Therapeutics