%0 Journal Article %A A. M. LANDS %A E. E. RICKARDS %A V. L. NASH %A K. Z. HOOPER %T THE PHARMACOLOGY OF VASODEPRESSOR COMPOUNDS STRUCTURALLY RELATED TO THE SYMPATHOMIMETIC AMINES %D 1947 %J Journal of Pharmacology and Experimental Therapeutics %P 297-305 %V 89 %N 3 %X 1. The pressor potency of 1-(p-hydroxyphenyl)-2-aminoethane (tyrarnine) is diminished by the addition of an hydroxyl group to the beta-carbon and by the addition of a methyl group to the nitrogen. 2. The replacement of one of the hydrogens of the amino group of 1-(p-hydroxyphenyl)-2-aminoethanol by ethyl, isopropyl, secondary butyl or tertiary butyl groups results in compounds that are strongly depressor in action. similar substitution by n-propyl, n-butyl and isobutyl groups results in compounds which exert only transient depressor action. 3. The presence of an alcoholic hydroxyl on the beta-carbon appears to be necessary for this action. 4. Those compounds which cause a prolonged fall in blood pressure are also most active in bringing about inhibition in those organs inhibited by epinephrine 1947 by The American Society for Pharmacology and Experimental Therapeutics %U https://jpet.aspetjournals.org/content/jpet/89/3/297.full.pdf