RT Journal Article
SR Electronic
T1 A CONTRIBUTION TO THE PHARMACOLOGY OF 5-NITRO-2-FURALDEHYDE SEMICARBAZONE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 324
OP 331
VO 85
IS 4
A1 JOHN C. KRANTZ, JR.
A1 WILLIAM E. EVANS, JR.
YR 1945
UL http://jpet.aspetjournals.org/content/85/4/324.abstract
AB 1. A pharmacodynamic and toxicologic investigation of 5-nitro-2-furaldehyde semicarbazone has been made in several species of animals. 2. In quantities, indicated by bacteriological studies as therapeutic, the compound appears to be tolerated without symptoms. Toxic doses produce hyperexcitability of the central nervous system in the rat. 3. In vitro, 5-nitro-2-furaldehyde semicarbazone diminished the activity of tissue dehydrogenases. 4. Preliminary ingestion trials in man have been recorded.