RT Journal Article
SR Electronic
T1 PHARMACOLOGICAL PROPERTIES OF ANTIHISTAMINE DRUGS, BENADRYL, PYRIBENZAMINE AND NEOANTERGAN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 247
OP 255
VO 89
IS 3
A1 T. R. SHERROD
A1 EARL R. LOEW
A1 H. F. SCHLOEMER
YR 1947
UL http://jpet.aspetjournals.org/content/89/3/247.abstract
AB 1. In dogs, equal doses of Benadryl, Pyribenzamine and Neoantergan were of the same effectiveness in antagonizing the depressor action of histamine, whereas the depressor action of acetylcholine was diminished only by Benadryl. 2. Pyribenzamine and Neoantergan may be more specific than Benadryl as regards antihistamine action, and are more potent relative to prevention of fatal histamine shock in guinea pigs. Benadryl exerted an antispasmodic action on the dog's intestine but not on the uterus and all the compounds diminished the spasmogenic action of histamine on the duodenum and uterus. Pyribenzamine and Neoantergan contracted the duodenum and uterus. 3. These antihistamine compounds enhanced the pressor response to epinephrine, the phenomenon being unrelated to a cardiac vagal blocking action. 1947 by The American Society for Pharmacology and Experimental Therapeutics