PT - JOURNAL ARTICLE AU - RICHARD G. HORTON AU - GEORGE B. KOELLE AU - BERNARD P. McNAMARA AU - HARRY J. PRATT TI - THE ACUTE TOXICITY OF DI-ISOPROPYL FLUOROPHOSPHATE DP - 1946 Aug 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 414--420 VI - 87 IP - 4 4099 - http://jpet.aspetjournals.org/content/87/4/414.short 4100 - http://jpet.aspetjournals.org/content/87/4/414.full SO - J Pharmacol Exp Ther1946 Aug 01; 87 AB - 1. The cholinergic signs observed in normal unanesthetized mice, rats, rabbits, dogs and cats after administration of di-isopropyl fluorophosphate (DFP) by different routes of administration have been described briefly. 2. The acute median lethal doses of DFP after intravenous administration in 52 rabbits, 38 dogs and 83 cats; subcutaneous injection in 50 mice, intramuscular injection in 60 rats; and oral administration in 45 mice and 50 rabbits have been determined. 3. The LD50's and the standard errors for the several series of experiments were as follows: [See table in the PDF file]