PT  - JOURNAL ARTICLE
AU  - G. L. CANTONI
AU  - G. EASTMAN
TI  - ON THE RESPONSE OF THE INTESTINE TO SMOOTH MUSCLE STIMULANTS
DP  - 1946 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 392--399
VI  - 87
IP  - 4
4099  - http://jpet.aspetjournals.org/content/87/4/392.short
4100  - http://jpet.aspetjournals.org/content/87/4/392.full
SO  - J Pharmacol Exp Ther1946 Aug 01; 87
AB  - 1. The effect of large doses of histamine, acetylcholine, pilocarpine, and potassium chloride on the responsiveness of isolated guinea pig intestine was investigated. 2. Maximal contractions obtained in response to a large dose of histamine, acetylcholine, pilocarpine, barium chloride, and mecholyl were followed by temporary depression of the contractile responsiveness of the intestinal strip. On the other hand, a maximal contraction in response to large doses of potassium chloride did not result in a decreased contractility of the preparation. 3. A small increase in the K/Ca ratio of the perfusion fluid, such as obtained by doubling the potassium content of Tyrode solution, was sufficient to neutralize the effect of large doses of histamine, acetylcholine, pilocarpine, barium chloride, etc.