TY - JOUR T1 - THE RELATIONSHIP BETWEEN THE LIPOID AFFINITY AND THE INSECTICIDAL ACTION OF 1,1-bis (p-FLUOROPHENYL) 2,2,2-TRICHLOROETHANE AND RELATED SUBSTANCES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 375 LP - 381 VL - 87 IS - 4 AU - S. KIRKWOOD AU - P. H. PHILLIPS Y1 - 1946/08/01 UR - http://jpet.aspetjournals.org/content/87/4/375.abstract N2 - The compound 1,1-bis(p-fluorophenyl) 2,2,2-trichloroethane which has insecticidal activity very near that of DDT has been shown to accumulate in the perirenal fat of rats to which it was fed. The compound 1,1-bis(p-chlorophenyl) 2,2,2-trifluoroethane which has little or no insecticidal activity did not accumulate in the perirenal fat of rats under similar conditions. This evidence points rather definitely to a relationship between lipoid affinity and insecticidal activity and as such offers an explanation for the mechanism of action of 1,1-bis(p-chlorophenyl) 2,2,2-trichloroethane and related insecticides as suggested by Läuger. The significance of these data and other evidence in the literature is discussed. ER -