RT Journal Article
SR Electronic
T1 THE ANTI-HISTAMINE ACTIVITY OF DIETHYLAMINOETHYL-DIHYDROANTHRACENE-CARBOXYLATE AND OTHER SUBSTANCE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 90
OP 95
VO 83
IS 1
A1 GERHARD LEHMANN
A1 JAMES W. YOUNG
YR 1945
UL http://jpet.aspetjournals.org/content/83/1/90.abstract
AB Diethylaminoethyl-dihydroanthracene-carboxylate provides 100 per cent protection to sensitized guinea pigs against one fatal dose of antigen. Diethylaminoethyl-xanthene-carboxylate is 70 per cent effective. Diethylaminoethyl-fluorene-carboxylate, aminophylline and epinephrine protect only 37 per cent of the animals. The dihydroanthracene derivative reduces the volume but not the acid concentration of histamine-induced gastric secretion. The dihydroanthracene derivative intensified the intradermal skin reaction produced by histamine. The increase in the resistance of the pulmonary circulation of the isolated perfused guinea pig's lung caused by epinephrine, histamine or anaphylactic reaction, is reduced by aminophylline and the dihydroanthracene derivative. The latter is more potent in its bronchodilator effect than aminophylline. The possibility that the main mechanism of aminophylline in bronchial asthma is the decrease in the resistance of the pulmonary circulation, is suggested.