%0 Journal Article %A GERHARD LEHMANN %T THE ACTION OF SOME SPASMOLYTIC SUBSTANCES ON UTERINE MOTILITY %D 1945 %J Journal of Pharmacology and Experimental Therapeutics %P 86-89 %V 83 %N 1 %X The effect on uterine motility of the diethylaminoethyl esters of dihydroanthracene-carboxylic acid, fluorene-carboxylic acid (Pavatrine), phenyl-tropic acid and of the tropic acid esters of tropine (atropine), diethylaminoethanol and diethylamino-dimethylpropanol (Syntropan) has been studied. Of these compounds, the dihydroanthracene derivative is the only one which reduces or abolishes motility of the isolated and intact rabbit's uterus and of longitudinal and circular strips taken from excised human uteri. Pavatrine and the phenyl-tropic acid ester abolish motility of both longitudinal and circular strips of the human uterus, however they usually cause contraction of the rabbit's uterus. The tropic acid esters have a spasmolytic effect only on circular strips of the human uterus. On the basis of these findings, it is suggested that the pain of primary dysmenorrhea may be due, at least in some cases, to spasm of the cervix uteri. The findings of this investigation make intelligible the contradictory results of animal experimentation and clinical investigation concerning the effectiveness of uterine spasmolytics. %U https://jpet.aspetjournals.org/content/jpet/83/1/86.full.pdf