RT Journal Article
SR Electronic
T1 THE POSTERIOR PITUITARY-LIKE ACTIVITY OF COMMERCIAL ANTERIOR PITUITARY PREPARATIONS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 11
OP 20
VO 83
IS 1
A1 S. E. DICKER
A1 H. HELLER
YR 1945
UL http://jpet.aspetjournals.org/content/83/1/11.abstract
AB 1. Nine commercial preparations of Anterior Pituitary Extracts and their fractions were investigated for their posterior pituitary activity. 2. The oxytocic, pressor and antidiuretic activities of each preparation were tested. The resistance to 2N sodium hydroxide of any of the posterior pituitary-like factors found was determined. 3. Seven out of the nine preparations were found to contain neligible amounts of posterior pituitary activity. One preparation contained per cc. the equivalent of 40 to 100 mU. of Pituitary (posterior lobe) Extract. The posterior pituitary-like activity of another extract varied considerably from batch to batch, amounting in one case to the equivalent of about 10 units of Pituitary (posterior lobe) Extract per cc.