TY - JOUR T1 - INFLUENCE OF TEMPERATURE, LIVER AND KIDNEY ON THE TOXICITY OF CAFFEINE IN BUFO ARENARUM HENSEL JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 303 LP - 309 VL - 82 IS - 3 AU - B. GÜNTHER AU - J. B. ODORIZ Y1 - 1944/11/01 UR - http://jpet.aspetjournals.org/content/82/3/303.abstract N2 - 1) Per unit body weight, small Bufo arenarum Hensel compared with large ones, have: a) more diuresis, and b) after the injection of caffeine a larger amount of xanthine derivatives eliminated. In not a single instance was more than 10% of the injected caffeine eliminated in two hours. 2) Toxicity of caffeine is much higher at low temperature (4°C.) and diminishes with thermal increase. 3) At low temperature symptomatology is more intense, diuresis ceases and death comes earlier. 4) Toxicity of caffeine is greater after certain operations and increases in the following order : 1st hepatectomy, 2nd ligature of both ureters, 3rd with both operations together. At 33°C. ligature of ureters considerably increases the toxic action of caffeine. ER -