PT  - JOURNAL ARTICLE
AU  - GEORGE A. EMERSON
TI  - SOME CIRCULATORY EFFECTS OF PRIVINE HYDROCHLORIDE
DP  - 1944 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 42--47
VI  - 82
IP  - 1
4099  - http://jpet.aspetjournals.org/content/82/1/42.short
4100  - http://jpet.aspetjournals.org/content/82/1/42.full
SO  - J Pharmacol Exp Ther1944 Sep 01; 82
AB  - Circulatory effects of privine HCl on intravenous injection are compared with those of some sympathomimetic amines. In dogs narcotized with pentobarbital, the minimal pressor dose is 1-2 x 10–5 mM./kg., while a maximum response is usually obtained with 5 x 10–5 to 10–4 mM./kg. Above this dose, privine generally causes cardiac irregularities which limit the pressor response. Tachyphylaxis occurs at about this dose. Atropine and cocaine do not appreciably influence the action of privine; 933F reduces but does not reverse the pressor action. Small doses of privine potentiate epinephrine but large doses are adrenolytic. Cheynes-Stokes' respiration often follows injection of large doses.