PT  - JOURNAL ARTICLE
AU  - ALBERT R. LATVEN
AU  - ARNOLD D. WELCH
TI  - SULFAMERAZINE (2—SULFANILAMIDO-4—METHYLPYRIMIDINE)
DP  - 1944 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 301--306
VI  - 81
IP  - 3
4099  - http://jpet.aspetjournals.org/content/81/3/301.short
4100  - http://jpet.aspetjournals.org/content/81/3/301.full
SO  - J Pharmacol Exp Ther1944 Jul 01; 81
AB  - The hemolytic anemia-producing properties of sulfapyridine, sulfamerazine and sulfadiazine have been evaluated in mice by determining the percentage incidence of anemia produced by various concentrations of sulfonamide in the blood. The concentration of sulfonamide in the blood necessary to produce a 50 per cent incidence of anemia was found to be: with sulfapyridine, 2.8 mgm., with sulfadiazine, 33.0 mgm., and with sulfamerazine, 31.0 mgm. per 100 cc. Although a high micromolar concentration of sulfonamide within the erythrocytes was required to produce anemia with sulfadiazine and sulfamerazine, sulfapyridine produced the same incidence of anemia with an erythrocytic concentration only about one-tenth as great. The possible clinical significance of these findings is discussed.