PT  - JOURNAL ARTICLE
AU  - K. UNNA
AU  - E. P. PICK
TI  - INHIBITION OF NERVOUS TRANSMISSION IN SYNAPSES AND END PLATES BY THIAMINE
DP  - 1944 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 294--300
VI  - 81
IP  - 3
4099  - http://jpet.aspetjournals.org/content/81/3/294.short
4100  - http://jpet.aspetjournals.org/content/81/3/294.full
SO  - J Pharmacol Exp Ther1944 Jul 01; 81
AB  - 1. Thiamine (5-15 mgm. per 100 cc.) inhibits the action of nicotine in the isolated intestine of rabbits and guinea pigs. Cocarboxylase has the same effect as thiamine. The action of drugs stimulating sympathetic or parasympathetic nerve endings is not influenced by thiamine. 2. This effect of thiamine is linked to the thiazole moiety of the thiamine molecule and appears to be analogous to the effect of certain sulfonamides. 3. Thiamine also inhibits the action of nicotine in the striated muscle of frogs. 4. The effect of thiamine upon the nicotine action is not influenced by prostigmine. 5. The processes involved in the inhibition of the nicotine action in synapses and in end plates at the myoneural junction are discussed.