RT Journal Article SR Electronic T1 STUDIES ON SHOCK INDUCED BY HEMORRHAGE VIII. THE INACTIVATION OF THE APOENZYME OF AMINO ACID OXIDASE AND LACTIC DEHYDROGENASE IN ANOXIA JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 240 OP 247 VO 81 IS 3 A1 MARGARET E. GREIG YR 1944 UL http://jpet.aspetjournals.org/content/81/3/240.abstract AB 1. Tissues which have been made anoxic show a decreased ability to metabolize lactic and amino acids. 2. This decreased oxidative ability is not due entirely to coenzyme destruction nor to an anaerobic accumulation of intermediate metabolites which inhibit oxidation. 3. A heat labile, non-dialyzable, enzyme like substance has been found in tissue extracts which inhibits lactic and amino acid oxidation. It is assumed that this is the same factor which inhibits oxidation in anoxic tissue. 4. This enzyme like substance appears to attack the apoenzyme or protein part of the oxidative enzyme systems.