PT  - JOURNAL ARTICLE
AU  - MARSHALL R. WARREN
AU  - HAROLD W. WERNER
TI  - THE CENTRAL STIMULANT ACTION OF SOME VASOPRESSOR AMINES
DP  - 1945 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 119--121
VI  - 85
IP  - 2
4099  - http://jpet.aspetjournals.org/content/85/2/119.short
4100  - http://jpet.aspetjournals.org/content/85/2/119.full
SO  - J Pharmacol Exp Ther1945 Oct 01; 85
AB  - The subcutaneous administration of seven commercial vasopressor amines in doses equal to fractional parts of the LD50 as determined at 26°C. showed that Benzedrine, Ephedrine, and Propadrine caused the greatest central stimulant action as measured by the total activity of white rats. Maximal stimulating effects observed for these three compounds were obtained with five, ten, and twenty per cent of the LD50 of Ephedrine; ten and twenty per cent of the LD50 of Propadrine; and twenty per cent of the LD50 of Benzedrine. Vonedrine caused a small amount of stimulation in the higher doses while Tuamine, Privine, and Neo-Synephrine had no significant effect in the doses employed. Twenty per cent of the LD50 seems to be the most suitable dosage level for preliminary screening tests since this dose alone produced maximal observed effects with all compounds.