RT Journal Article
SR Electronic
T1 BIOLOGICAL COMPARISON OF LOCAL ANAESTHETICS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 78
OP 84
VO 85
IS 1
A1 EDITH BÜLBRING
A1 ISABELLA WAJDA
YR 1945
UL http://jpet.aspetjournals.org/content/85/1/78.abstract
AB 1. Two methods are described for testing the potency of local anaesthetics. 2. With a certain range of concentrations a linear relationship exists between the logarithm of the concentration of the local anaesthetics which were examined and the time at which plexus anaesthesia in frogs develops. 3. When the intracutaneous wheal in guinea-pigs is used, a similar linear relation exists between the logarithm of the concentration of the local anaesthetic and an index expressing both intensity and duration of anaesthesia. 4. The lines for β-eucaine, procaine and nupercaine, though parallel to each other, are not parallel to that for cocaine. It is suggested, therefore, to use procaine as a standard of comparison. It was observed that when adrenaline was added to procaine and the mixture was compared with cocaine by the guinea-pig method, the log dose-effect lines became parallel.