TY - JOUR T1 - FURTHER OBSERVATIONS ON THE PRESSOR ACTION OF OPTICAL ISOMERS OF SYMPATHOMIMETIC AMINES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 70 LP - 73 VL - 85 IS - 1 AU - E. E. SWANSON AU - FRANK A. STELDT AU - K. K. CHEN Y1 - 1945/09/01 UR - http://jpet.aspetjournals.org/content/85/1/70.abstract N2 - 1. Of the sympathomimetic drugs, the l-mandelate of optically active aromatic amines appears to be more active in raising the blood pressure of pithed dogs than the d-mandelate of the same isomer, as exemplified by l-ephedrine and other previously reported compounds. 2. No difference in pressor action can be detected between the enantiomorphous mandelates of optically inactive amines, such as β-phenylethylamine and tyramine. 3. Neither l- nor d-mandelic acid raises blood pressure. 4. Of the 2-aminoheptane sulfates, the d-isomer having levorotation in water is almost twice as active as the l-isomer, which has a dextrorotation, the dl-isomer being intermediate between the two. 5. Differences in pressor action can be also detected between the enantiomorphous mandelates of d-2-aminoheptane and those of l-2-aminoheptane. ER -