PT  - JOURNAL ARTICLE
AU  - DIRAN YEGIAN
AU  - VERA BUDD
TI  - THE PERMEABILITY OF MYCOBACTERIA TO SULFONAMIDES AND SULFONAMIDE-LIKE AGENTS
DP  - 1945 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 318--324
VI  - 84
IP  - 4
4099  - http://jpet.aspetjournals.org/content/84/4/318.short
4100  - http://jpet.aspetjournals.org/content/84/4/318.full
SO  - J Pharmacol Exp Ther1945 Aug 01; 84
AB  - Evidence has been obtained by means of a newly described technique that sulfonamides and sulfonamide-like agents enter mycobacterial cells and the possible relation between this fact and the mechanism of bacteriostasis by these agents is discussed. Sulfonamide-fast mycobacteria produce large amounts of diazotizable material and the development of drug-fastness does not appear to depend upon the change in permeability or binding of the sulfonamide to the bacterial cells. Mycobacteria killed by various techniques are demonstrated to bind more sulfonamide than do living organisms and the possible significance of this observation is discussed.