RT Journal Article
SR Electronic
T1 THE PREPARATION OF EXTRACTS FROM OXIDIZED MARINE AND OTHER OILS FOR REDUCING THE BLOOD PRESSURE IN EXPERIMENTAL AND HUMAN CHRONIC HYPERTENSION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 128
OP 135
VO 84
IS 2
A1 ARTHUR GROLLMAN
YR 1945
UL http://jpet.aspetjournals.org/content/84/2/128.abstract
AB A number of refined oils derived from marine fishes when administered orally are effective in reducing the blood pressure in experimentally induced hypertension in laboratory animals (rats, dogs). Comparable effects were elicited in three human patients suffering from hypertension. Among oils of vegetable and animal origin, only tung oil was found to have an effect in reducing the blood pressure in hypertensive animals. Oxidation enhances the activity of certain oils; saponification prior to oxidation in some cases further increases their effectiveness. The blood pressure reducing capacity of the oils is independent of their original vitamin A content, and is retained after destruction of this vitamin by oxidation. Fractional separation of the oil by distillation in vacuo, freezing, or distribution between aqueous organic solvents, partially effects a concentration of the effective blood pressure reducing agent. By adsorption on a synthetic resin and desorption with aqueous alkali, it is possible to obtain the active principle in aqueous solution.