PT  - JOURNAL ARTICLE
AU  - E. D. BROWN
TI  - OBSERVATIONS ON THE EFFECT QF EPINEPHRINE ON THE MEDULLARY CENTERS
DP  - 1916 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 195--203
VI  - 8
IP  - 4
4099  - http://jpet.aspetjournals.org/content/8/4/195.short
4100  - http://jpet.aspetjournals.org/content/8/4/195.full
SO  - J Pharmacol Exp Ther1916 Apr 01; 8
AB  - 1. In summing up the results obtained from the experiments, they tend to show that when epinephrine is perfused through the cerebral circulation, it may in a certain per cent of cases cause a slowing of the heart and that this slowing is at least in part due to a direct stimulation of the vagus center. 2. There is certain evidence which strongly suggests the probability that the drug also stimulates the vasomotor center. 3. The effect on the respiratory center is very variable. There is evidence of both stimulation and depression and neither of these effects appear to be governed by the size of the dose of the drug.