TY - JOUR T1 - METABOLISM, TOXICITY, AND MANNER OF ACTION OF GOLD COMPOUNDS IN THE TREATMENT OF ARTHRITIS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 275 LP - 278 VL - 83 IS - 4 AU - WALTER D. BLOCK AU - ELIZABETH L. KNAPP Y1 - 1945/04/01 UR - http://jpet.aspetjournals.org/content/83/4/275.abstract N2 - 1. The in vitro effect of various gold-containing compounds upon the oxygen consumption of liver and kidney slices from healthy white rats was determined. 2. The oxygen consumption was inhibited by the inorganic, ionizable compounds, gold chloride and gold sodium thiosulfate, and to a lesser degree by colloidal gold sulfide. The organic, non-ionizable compounds, sodium succinimido-aurate, gold sodiumn thiomalate, and gold thioglucose, did not cause any inhibition. At equal molar concentrations of gold the degree of inhibition was greater for kidney than for liver slices. 3. Solutions of gold chloride varying in ionic concentration from M/250 to M/5000 produced the same relative degree of inhibition on the oxygen consumption of liver and kidney slices. 4. The significance of these findings in relation to earlier studies on the distribution of gold in tissues is discussed briefly. ER -