PT  - JOURNAL ARTICLE
AU  - ROSE, CHARLES L.
AU  - FINK, ROBERT D.
AU  - HARRIS, PAUL N.
AU  - CHEN, K. K.
TI  - THE EFFECT OF HEPATOTOXIC ALKALOIDS ON THE PROTHROMBIN TIME OF RATS
DP  - 1945 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 265--269
VI  - 83
IP  - 4
4099  - http://jpet.aspetjournals.org/content/83/4/265.short
4100  - http://jpet.aspetjournals.org/content/83/4/265.full
SO  - J Pharmacol Exp Ther1945 Apr 01; 83
AB  - 1. Senecionine, retrorsine, pterophine, spartioidine, and monocrotaline, in sufficient doses, prolong the plasma prothrombin time of rats. Sceleratine has a similar effect, but to a less degree. 2. Retronecine, retronecic lactone, and monocrotalic acid—the degradation products of retrorsine and monocrotaline—do not cause liver necrosis in mice and rats, or hypoprothrombinemia in rats. 3. Feeding of a vitamin K preparation, menadione, to rats appears to inhibit the hypoprothrombinemic action of retrorsine and monocrotaline. 4. Variation of the protein content of the diet and addition of brewer's yeast and liver extract have no appreciable effect upon the hypoprothrombinemic action of senecionine.