TY - JOUR T1 - CHEMOTHERAPY OF FILARIASIS IN THE COTTON RAT BY ADMINISTRATION OF NEOSTAM AND OF NEOSTIBOSAN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 189 LP - 196 VL - 81 IS - 2 AU - JAMES T. CULBERTSON AU - HARRY M. ROSE Y1 - 1944/06/01 UR - http://jpet.aspetjournals.org/content/81/2/189.abstract N2 - The repeated injection of neostam or of neostibosan to cotton rats infected with the filarial worm Litomosoides carinii kills the adult parasites which occur in the pleural space of the animals and leads to the gradual disappearance of microfilariae from the peripheral blood. Even a single dose (40 mgm.) of one of these drugs (neostam) has proved sufficient to eliminate the parasite from some animals. The adult parasites appear to be decidedly more susceptible to the action of neostam or of neostibosan than are the microfilariae, for within two weeks from the beginning of treatment, the adult worms are usually dead although the numbers of microfilaria in the tail blood at this time are essentially the same as before treatment began. Neostam and neostibosan in concentrations of from 1 to 5 mg. per cent or more kill adult Litomosoides carinii in vitro after approximately four days at 37°C. ER -