RT Journal Article SR Electronic T1 A QUANTITATIVE STUDY OF THE ANALGESIA PRODUCED BY OPIUM ALKALOIDS, INDIVIDUALLY AND IN COMBINATION WITH EACH OTHER, IN NORMAL MAN JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 1 OP 37 VO 8 IS 1 A1 DAVID I. MACHT A1 N. B. HERMAN A1 CHARLES S. LEVY YR 1916 UL http://jpet.aspetjournals.org/content/8/1/1.abstract AB 1. A convenient method for studying cutaneous pain sensation in man quantitatively and expressing the results in absolute physical units has been described. 2. The principal opium alkaloids in respect to their analgesic power can be arranged in the following order: Morphin, papaverin, codein, narcotin, narcein, and thebain. 3. It has been found that a combination of morphin and narcotin, and also a combination of the total opium alkaloids is much more effective than the quantity of morphin they contain would be if given alone. 4. It has been further found that in the case of one of us, showing an idiosyncrasy for morphin, that alkaloid produced a heightening instead of a lowering of the threshold of pain, which phenomenon, however, disappeared on administering morphin in conjunction with narcotin.