PT  - JOURNAL ARTICLE
AU  - E. GORDON YOUNG
AU  - W. W. HAWKINS
TI  - THE ROLE OF PYROGENS IN THE ALLEGED LEUKOCYTIC RESPONSE TO ALLANTOIN
DP  - 1944 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 10--16
VI  - 81
IP  - 1
4099  - http://jpet.aspetjournals.org/content/81/1/10.short
4100  - http://jpet.aspetjournals.org/content/81/1/10.full
SO  - J Pharmacol Exp Ther1944 May 01; 81
AB  - The effects of administering allantoin orally and parenterally to man, dog and rabbit have been tested experimentally with relation to total white cell and differential counts. No effect from single or repeated oral doses of 0.26 to 7.35 gm. has been demonstrated. Marked leukocytosis with neutrophilia within 3 to 5 hours has been observed in eleven human male subjects after intravenous and subcutaneous administration of doses from 50 to 240 mgm. in Ringer's solution. These effects have been shown to be due to pyrogenic substances in the solvent medium. Pure allantoin in sterile saline made up from double-distilled water was without any effect on man. The use of leukocytosis as a test for pyrogens is suggested in relation to intravenous therapy.