RT Journal Article
SR Electronic
T1 THE INFLUENCE OF THIAMIN-DEFICIENCY ON WORK PERFORMANCE IN RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 362
OP 372
VO 80
IS 4
A1 MICHAEL KNIAZUK
A1 HANS MOLITOR
A1 JAMES HUNTER
A1 HARRY KASHA
A1 WALTER O'SHANNY
YR 1944
UL http://jpet.aspetjournals.org/content/80/4/362.abstract
AB 1. A method for the recording of the work-performance of swimming rats is described. This method permits the discovery of minor impairments in the physical fitness of these animals and affords a means to measure and record quantitively the changes of muscular performance. 2. Various factors influencing these tests have been investigated and their importance is analyzed. 3. Administration of a thiamin-deficient diet results in a rapid and marked decrease of physical fitness. 4. Administration of thiamin restores promptly the impairment of work-performance due to thiamin deficiency. 5. This reduction of work-performance is not caused by a reduced intake of food. 6. Administration of thiamin, even in large doses, to non-deficient animals is without beneficial effect on their work performance. 7. Reduction of food intake alone is not accompanied by a decrease in work-performance, as long as a nutritionally adequate diet is provided.