@article {KNIAZUK362, author = {MICHAEL KNIAZUK and HANS MOLITOR and JAMES HUNTER and HARRY KASHA and WALTER O{\textquoteright}SHANNY}, title = {THE INFLUENCE OF THIAMIN-DEFICIENCY ON WORK PERFORMANCE IN RATS}, volume = {80}, number = {4}, pages = {362--372}, year = {1944}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {1. A method for the recording of the work-performance of swimming rats is described. This method permits the discovery of minor impairments in the physical fitness of these animals and affords a means to measure and record quantitively the changes of muscular performance. 2. Various factors influencing these tests have been investigated and their importance is analyzed. 3. Administration of a thiamin-deficient diet results in a rapid and marked decrease of physical fitness. 4. Administration of thiamin restores promptly the impairment of work-performance due to thiamin deficiency. 5. This reduction of work-performance is not caused by a reduced intake of food. 6. Administration of thiamin, even in large doses, to non-deficient animals is without beneficial effect on their work performance. 7. Reduction of food intake alone is not accompanied by a decrease in work-performance, as long as a nutritionally adequate diet is provided.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/80/4/362}, eprint = {https://jpet.aspetjournals.org/content/80/4/362.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }