RT Journal Article
SR Electronic
T1 TISSUE ALDEHYDES AND THEIR REACTION WITH AMINES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 132
OP 138
VO 80
IS 2
A1 KURT A. OSTER
A1 MICHAEL G. MULINOS
YR 1944
UL http://jpet.aspetjournals.org/content/80/2/132.abstract
AB 1. The staining reaction for aldehydes with fuchsin sulfurous acid is described for liver and kidney tissues of 5 species of animals. 2. The formation of condensation products (Schiff's base) between tissue aldehydes and various amines and the influence of hydrogen ion concentration is described. 3. The significance of the formation of Schiff's base as a detoxification mechanism and the interference of p-amino benzoic acid with the antiseptic powers of the sulfonamides is discussed.