TY - JOUR T1 - METHEMOGLOBINEMIA AFTER ADMINISTRATION OF p-AMINOACETOPHENONE AND p-AMINOPROPIOPHENONE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 31 LP - 38 VL - 80 IS - 1 AU - J. M. VANDENBELT AU - CARL PFEIFFER AU - MARGARET KAISER AU - MARGARET SIBERT Y1 - 1944/01/01 UR - http://jpet.aspetjournals.org/content/80/1/31.abstract N2 - The compounds, p-aminoacetophenone and p-aminopropiophenone, whether given orally or intravenously, are highly active in forming methemoglobin. The latter is the more active, being as active as p-dinitrobenzene, but differing in that its effect is less rapid and more prolonged. Death occurs at 95% methemoglobinemia and recovery may occur with 87% methemoglobinemia. Due to the desirable chemical and pharmacological properties of p-aminopropiophenone this compound may prove of value for the experimental production of methemoglobinemia and anoxia. ER -